Hydroxychloroquine pharmacokinetic in COVID-19 critically ill patients: an observational cohort study.
Identifieur interne : 000D91 ( Main/Exploration ); précédent : 000D90; suivant : 000D92Hydroxychloroquine pharmacokinetic in COVID-19 critically ill patients: an observational cohort study.
Auteurs : Benoit Painvin [France] ; Pauline Guillot [France] ; Marie-Clémence Verdier [France] ; Arnaud Gacouin [France] ; Adel Maamar [France]Source :
- Intensive care medicine [ 1432-1238 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Atteinte rénale aigüe (épidémiologie), Betacoronavirus (MeSH), Créatinine (sang), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (pharmacocinétique), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Maladie grave (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (épidémiologie), Période (MeSH), Relation dose-effet des médicaments (MeSH), Sujet âgé (MeSH), Surveillance des médicaments (MeSH), Unités de soins intensifs (MeSH).
- MESH :
- pharmacocinétique : Hydroxychloroquine.
- sang : Créatinine.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Hydroxychloroquine.
- épidémiologie : Atteinte rénale aigüe, Infections à coronavirus, Pneumopathie virale.
- Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Maladie grave, Mâle, Pandémies, Période, Relation dose-effet des médicaments, Sujet âgé, Surveillance des médicaments, Unités de soins intensifs.
English descriptors
- KwdEn :
- Acute Kidney Injury (epidemiology), Aged (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Creatinine (blood), Critical Illness (MeSH), Dose-Response Relationship, Drug (MeSH), Drug Monitoring (MeSH), Female (MeSH), Half-Life (MeSH), Humans (MeSH), Hydroxychloroquine (pharmacokinetics), Hydroxychloroquine (therapeutic use), Intensive Care Units (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology).
- MESH :
- chemical , blood : Creatinine.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Acute Kidney Injury, Coronavirus Infections, Pneumonia, Viral.
- chemical , pharmacokinetics : Hydroxychloroquine.
- chemical , therapeutic use : Hydroxychloroquine.
- Aged, Betacoronavirus, Critical Illness, Dose-Response Relationship, Drug, Drug Monitoring, Female, Half-Life, Humans, Intensive Care Units, Male, Middle Aged, Pandemics.
DOI: 10.1007/s00134-020-06142-y
PubMed: 32514594
PubMed Central: PMC7276495
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine pharmacokinetic in COVID-19 critically ill patients: an observational cohort study.</title><author><name sortKey="Painvin, Benoit" sort="Painvin, Benoit" uniqKey="Painvin B" first="Benoit" last="Painvin">Benoit Painvin</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France. benoit.painvin@chu-rennes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Guillot, Pauline" sort="Guillot, Pauline" uniqKey="Guillot P" first="Pauline" last="Guillot">Pauline Guillot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verdier, Marie Clemence" sort="Verdier, Marie Clemence" uniqKey="Verdier M" first="Marie-Clémence" last="Verdier">Marie-Clémence Verdier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie Biologique, Centre Hospitalier Universitaire Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie Biologique, Centre Hospitalier Universitaire Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="Gacouin, Arnaud" sort="Gacouin, Arnaud" uniqKey="Gacouin A" first="Arnaud" last="Gacouin">Arnaud Gacouin</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="Maamar, Adel" sort="Maamar, Adel" uniqKey="Maamar A" first="Adel" last="Maamar">Adel Maamar</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32514594</idno><idno type="pmid">32514594</idno><idno type="doi">10.1007/s00134-020-06142-y</idno><idno type="pmc">PMC7276495</idno><idno type="wicri:Area/Main/Corpus">000E82</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000E82</idno><idno type="wicri:Area/Main/Curation">000E82</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000E82</idno><idno type="wicri:Area/Main/Exploration">000E82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine pharmacokinetic in COVID-19 critically ill patients: an observational cohort study.</title><author><name sortKey="Painvin, Benoit" sort="Painvin, Benoit" uniqKey="Painvin B" first="Benoit" last="Painvin">Benoit Painvin</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France. benoit.painvin@chu-rennes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Guillot, Pauline" sort="Guillot, Pauline" uniqKey="Guillot P" first="Pauline" last="Guillot">Pauline Guillot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Verdier, Marie Clemence" sort="Verdier, Marie Clemence" uniqKey="Verdier M" first="Marie-Clémence" last="Verdier">Marie-Clémence Verdier</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Pharmacologie Biologique, Centre Hospitalier Universitaire Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie Biologique, Centre Hospitalier Universitaire Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="Gacouin, Arnaud" sort="Gacouin, Arnaud" uniqKey="Gacouin A" first="Arnaud" last="Gacouin">Arnaud Gacouin</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author><author><name sortKey="Maamar, Adel" sort="Maamar, Adel" uniqKey="Maamar A" first="Adel" last="Maamar">Adel Maamar</name><affiliation wicri:level="3"><nlm:affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName><orgName type="university">Université de Rennes 1</orgName></affiliation></author></analytic><series><title level="j">Intensive care medicine</title><idno type="eISSN">1432-1238</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Kidney Injury (epidemiology)</term><term>Aged (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Creatinine (blood)</term><term>Critical Illness (MeSH)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Drug Monitoring (MeSH)</term><term>Female (MeSH)</term><term>Half-Life (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (pharmacokinetics)</term><term>Hydroxychloroquine (therapeutic use)</term><term>Intensive Care Units (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Atteinte rénale aigüe (épidémiologie)</term><term>Betacoronavirus (MeSH)</term><term>Créatinine (sang)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hydroxychloroquine (pharmacocinétique)</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (épidémiologie)</term><term>Maladie grave (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (épidémiologie)</term><term>Période (MeSH)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Surveillance des médicaments (MeSH)</term><term>Unités de soins intensifs (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Creatinine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Acute Kidney Injury</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Créatinine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Atteinte rénale aigüe</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>Critical Illness</term><term>Dose-Response Relationship, Drug</term><term>Drug Monitoring</term><term>Female</term><term>Half-Life</term><term>Humans</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Femelle</term><term>Humains</term><term>Maladie grave</term><term>Mâle</term><term>Pandémies</term><term>Période</term><term>Relation dose-effet des médicaments</term><term>Sujet âgé</term><term>Surveillance des médicaments</term><term>Unités de soins intensifs</term></keywords></textClass></profileDesc></teiHeader></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32514594</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN><JournalIssue CitedMedium="Internet"><Volume>46</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Intensive care medicine</Title><ISOAbbreviation>Intensive Care Med</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine pharmacokinetic in COVID-19 critically ill patients: an observational cohort study.</ArticleTitle><Pagination><MedlinePgn>1772-1773</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-020-06142-y</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Painvin</LastName><ForeName>Benoit</ForeName><Initials>B</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0320-9876</Identifier><AffiliationInfo><Affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France. benoit.painvin@chu-rennes.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guillot</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verdier</LastName><ForeName>Marie-Clémence</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Laboratoire de Pharmacologie Biologique, Centre Hospitalier Universitaire Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gacouin</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maamar</LastName><ForeName>Adel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 2 rue Henri le Guilloux, 35033, Rennes Cedex 9, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculté de Médecine, Université de Rennes 1, Unité INSERM CIC 1414, IFR 140, Rennes, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Intensive Care Med</MedlineTA><NlmUniqueID>7704851</NlmUniqueID><ISSNLinking>0342-4642</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>AYI8EX34EU</RegistryNumber><NameOfSubstance UI="D003404">Creatinine</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D058186" MajorTopicYN="N">Acute Kidney Injury</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003404" MajorTopicYN="N">Creatinine</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016903" MajorTopicYN="N">Drug Monitoring</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006207" MajorTopicYN="N">Half-Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32514594</ArticleId><ArticleId IdType="doi">10.1007/s00134-020-06142-y</ArticleId><ArticleId IdType="pii">10.1007/s00134-020-06142-y</ArticleId><ArticleId IdType="pmc">PMC7276495</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Rheumatol. 2015 Nov;42(11):2092-7</Citation><ArticleIdList><ArticleId IdType="pubmed">26428205</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation><ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId></ArticleIdList></Reference><Reference><Citation>Lupus. 2018 Apr;27(5):847-852</Citation><ArticleIdList><ArticleId IdType="pubmed">28862574</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Pharmacol Ther. 2020 Aug;108(2):253-263</Citation><ArticleIdList><ArticleId IdType="pubmed">32285930</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Apr 07;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32255489</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Région Bretagne</li></region><settlement><li>Rennes</li></settlement><orgName><li>Université de Rennes 1</li></orgName></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Painvin, Benoit" sort="Painvin, Benoit" uniqKey="Painvin B" first="Benoit" last="Painvin">Benoit Painvin</name></region><name sortKey="Gacouin, Arnaud" sort="Gacouin, Arnaud" uniqKey="Gacouin A" first="Arnaud" last="Gacouin">Arnaud Gacouin</name><name sortKey="Gacouin, Arnaud" sort="Gacouin, Arnaud" uniqKey="Gacouin A" first="Arnaud" last="Gacouin">Arnaud Gacouin</name><name sortKey="Guillot, Pauline" sort="Guillot, Pauline" uniqKey="Guillot P" first="Pauline" last="Guillot">Pauline Guillot</name><name sortKey="Maamar, Adel" sort="Maamar, Adel" uniqKey="Maamar A" first="Adel" last="Maamar">Adel Maamar</name><name sortKey="Maamar, Adel" sort="Maamar, Adel" uniqKey="Maamar A" first="Adel" last="Maamar">Adel Maamar</name><name sortKey="Verdier, Marie Clemence" sort="Verdier, Marie Clemence" uniqKey="Verdier M" first="Marie-Clémence" last="Verdier">Marie-Clémence Verdier</name><name sortKey="Verdier, Marie Clemence" sort="Verdier, Marie Clemence" uniqKey="Verdier M" first="Marie-Clémence" last="Verdier">Marie-Clémence Verdier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D91 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D91 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32514594
|texte= Hydroxychloroquine pharmacokinetic in COVID-19 critically ill patients: an observational cohort study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32514594" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
| This area was generated with Dilib version V0.6.37. |  |